Pharm 5 Crossword
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Down:
1) Cardiotoxicity, peripheral neuropathy, alopecia, anaphalaxis2) Can cause peripheral neuropathy, ototoxicity, and severe kidney damage, so hydrate pt, give diuretic, give Amophistine, and then drug.4) DO NOT mix with Pentostatin because of likelihood of fatal pulmonary toxicity.5) Peripheral neuropathy, but bone sparing.6) QT prolongation, hepatic toxicity. Do not give to pt with liver disease. Black box: mortality risk, severe neutropenia, hypersensitivity, and fluid retention.7) delayed bone marrow suppression, pulmonary toxicity. Give steroids, check lung function and watch CBCs.8) give with Vit. B12, folic acid, and steroids.10) Cardiac toxicity. Give Totect and Zinecard to reduce toxicity.11) Estrogenic AE. Take PO on empty stomach.13) urinalysis, hydration, Mesna, drug. causes urotoxicity, CNS toxicity, bone marrow suppression.14) CAN give with Allopurinol and Febuxistat.16) interacts with smoking, so dose adjust and re-adjust.17) severe bone marrow suppression, some peripheral neuropathy.18) give with leucovorine, causes PPE19) peripheral sensory neuropathy intensified by cold.20) Sever vesicant.22) Electrolyte imbalance, nephro and ototoxicity.23) give with B12 and folic acid.25) irreversible ammenorhea and premature menopause.28) Anaphalaxis, very commonly combined with other drugs, highly emetogenic.29) Take on an empty stomach, DO NOT CRUSH. Can cause convulsions.33) Hepatotoxicity. |
Across:
3) bone marrow toxicity and pulmonary infiltrates.9) MAO Inhibitor12) Black box: neutropenia, severe hypersensitivity.15) Affects the islet cells and causes sever kidney damage. Check renal function and blood sugars.21) cross BBB so used in brain cancers.24) peripheral neuropathy and pulmonary infiltrates.26) Severe diarrhea (early and late) give with IV atropine if early, and lopiramide for late.27) liver toxicity. Do LFTs.30) Neurotoxicity (CNS)31) Give with leucovorin.32) bone marrow suppression in 98% of pts.34) Much lower incidence of AE, but watch for pulmonary infaltrates.35) Enhances effects of Warfarin36) QT prolongation, kidney.37) bluish green sweat.38) DO NOT mix with Fludarabine because of likelihood of fatal pulmonary toxicity.39) Liver damage stuff, a xanthine oxidase, so a possibility of gout. Cannot treat that gout with Allopurinol or Febuxistat, though.40) Local administration41) chemical arachnoiditis. coadminister with steroids.42) Take with food. |
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