Pharm 5 Crossword
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Down:
1) Sever vesicant.2) peripheral sensory neuropathy intensified by cold.5) Cardiotoxicity, peripheral neuropathy, alopecia, anaphalaxis6) Severe diarrhea (early and late) give with IV atropine if early, and lopiramide for late.7) DO NOT mix with Pentostatin because of likelihood of fatal pulmonary toxicity.8) Peripheral neuropathy, but bone sparing.9) chemical arachnoiditis. coadminister with steroids.15) Liver damage stuff, a xanthine oxidase, so a possibility of gout. Cannot treat that gout with Allopurinol or Febuxistat, though.17) Anaphalaxis, very commonly combined with other drugs, highly emetogenic.18) bone marrow toxicity and pulmonary infiltrates.20) DO NOT mix with Fludarabine because of likelihood of fatal pulmonary toxicity.21) Enhances effects of Warfarin22) Cardiac toxicity. Give Totect and Zinecard to reduce toxicity.23) Electrolyte imbalance, nephro and ototoxicity.26) Estrogenic AE. Take PO on empty stomach. |
Across:
3) interacts with smoking, so dose adjust and re-adjust.4) give with Vit. B12, folic acid, and steroids.8) Local administration9) delayed bone marrow suppression, pulmonary toxicity. Give steroids, check lung function and watch CBCs.10) give with leucovorine, causes PPE11) CAN give with Allopurinol and Febuxistat.12) QT prolongation, hepatic toxicity. Do not give to pt with liver disease. Black box: mortality risk, severe neutropenia, hypersensitivity, and fluid retention.13) Affects the islet cells and causes sever kidney damage. Check renal function and blood sugars.14) liver toxicity. Do LFTs.16) Hepatotoxicity.19) QT prolongation, kidney.21) Neurotoxicity (CNS)24) MAO Inhibitor25) give with B12 and folic acid.27) cross BBB so used in brain cancers.28) bone marrow suppression in 98% of pts.29) urinalysis, hydration, Mesna, drug. causes urotoxicity, CNS toxicity, bone marrow suppression.30) Give with leucovorin.31) Black box: neutropenia, severe hypersensitivity.32) Take on an empty stomach, DO NOT CRUSH. Can cause convulsions.33) Much lower incidence of AE, but watch for pulmonary infaltrates.34) Can cause peripheral neuropathy, ototoxicity, and severe kidney damage, so hydrate pt, give diuretic, give Amophistine, and then drug.35) bluish green sweat.36) irreversible ammenorhea and premature menopause.37) peripheral neuropathy and pulmonary infiltrates.38) Take with food.39) severe bone marrow suppression, some peripheral neuropathy. |
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